This will create an entry in the boot menu with the name “ Launch Windows 10 Safe Mode”.
If that’s the case, then rapidly press F8 key while Windows 10 is loading and you should see startup options in which Safe Mode option will also be available. If you are still using an older PC that runs on older BIOS and also has a hard drive instead of SSD, then the F8 trick may work on your Windows 10 PC as well. However, the boot speed depends on your PC’s BIOS and whether you are using SSD or not. Unfortunately, Windows 8 and Windows 10 boot too fast (with the right hardware) that the F8 keystroke is not even recognized. Pressing F8 while Windows is loading has always been the best way to boot Windows into Safe Mode. Method #2: Press F8 to Boot into Windows 10 Safe Mode
So you will have to go to System Configuration dialog again and uncheck “ Safe Mode” under Windows 10. However, this change is permanent and Windows 10 will always load in the Safe Mode. When restarted, Windows 10 will launch in the Safe Mode. When you will click “ OK” to apply the changes, you will be prompted to restart immediately or later. Otherwise, “Alternate shell” and “Network” modes are also available for launching Safe Mode with Command Prompt or Network access.